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So I think those are the four major factors that we are constantly monitoring and will have an effect on next year as well. It certainly is the largest we operate in with gMG, in particular, 60,000 to 80,000 patients in the U.S. alone. Thanks for taking the questions. On Wednesday, Alexion reported revenue for the first quarter of 2020 of $1.4 billion, 27% higher than a year earlier. No, I think that's the reason, Josh, for doing the buyback and to have the approach that is both balanced as well as flexible. While SOLIRIS and ULTOMIRIS both have an incredibly strong value proposition as innovative therapies, the key to our success in atypical HUS goes well beyond the treatment themselves. With that, let's turn to neurology. We are at the top of the hour so we'll take one more question. Halper Sadeh LLP Continues to Investigate the Following Mergers; Shareholders Are Encouraged to Contact the Firm - RP, OXFD, FFG, MDCA, ALXN, CHNG vendredi, … We believe significant value lies ahead, as we continue to execute on our strategy to create shareholder value. In terms of product revenue, updated guidance for SOLIRIS and ULTOMIRIS is $4,725 million to $4,755 million, while guidance for our metabolic business is now $785 million to $800 million. Alexion Pharmaceuticals, Inc.ALXN posted better-than-expected results for the first quarter of 2020 but trimmed its outlook for the year. Our pipeline now includes 20 development programs, up from four at the end of 2017, with a potential for 10 launches by 2023. I mean, first of all, we do see this as a very large market. As a result of the strong foundation we have established, we're also well positioned to continue delivering on our ambition of double-digit revenue growth. Yes. Starting on the left, we have the once-weekly ULTOMIRIS subcutaneous program that I mentioned earlier, on track for filing in the third quarter of next year. The second is the queue of new patients and the new patient adds, which, as you can imagine, it takes time for patients from the time of identification to vaccination, reimbursement and actually getting on therapy. Operator? We have achieved our initial ambition in this area by establishing ULTOMIRIS as the market leader in PNH, with more than 70% conversion in the U.S. We launched ULTOMIRIS for aHUS in the U.S. last October and are on track to achieve our goal of 70% conversion for SOLIRIS within two years. Questions and Answers. So John, 2040, 2050 PNH? Thanks. As I said, we're in a position of strength. In the U.S., the field force is still not back. Turning first to Slide 23. While still important, we'll shift from a heavily weighted focus on demand generation to a multifaceted approach that is similar to our comprehensive atypical HUS model. We've made significant investments in our R&D portfolio, transforming it from just a handful of C5 programs in 2017 to one that now includes 20 clinical stage programs across 11 assets. In the quarter, we received approval for ULTOMIRIS in atypical HUS in the EU. The only thing I wanted to add, I think it's been covered really well is to end on a positive note. Brian Goff -- Chief commercial and global operations officer. Patients on factor Xa inhibitors, who experience life-threatening or severe bleeds, often face sudden and uncontrolled bleeding. Given the evolving landscape in FcRn, we're shifting our approach to an entirely subcutaneous route of administration for both warm autoimmune hemolytic anemia and generalized myasthenia gravis. The company is expected to report earnings of $2.59/share on revenue of $1.429 billion. ET. Yes. And so it tends to be more front and center in terms of the acute nature of the conversions. Today's call will be led by Ludwig Hantson, our CEO. Turning to Slide 20. Alexion Pharmaceuticals Inc (NASDAQ: ALXN) Q4 2019 Earnings Conference Call January 30, 2020. We have significantly increased our free cash flow over the last few years and are committing to a minimum share repurchase of $500 million to $550 million in 2020 and at least an average of one-thirds of free cash flow annually from 2021 through 2023. Why we're focusing on buyback? I think the only thing I would add is, it's probably what you would expect in terms of severity and life-threatening status of the indications, if you stratify that way. So we're moving earlier in the course of the disease, in addition, as I said, we will be pursuing MG with our own FcRn program, 1830. Hey, good morning guys. Good morning Jeff. Today, I couldn't be prouder to share that we've achieved that 70% conversion and established ULTOMIRIS as the standard of care in the U.S. And we did so within 18 months, six months ahead of our initial goal. And I really can't comment on that, but we will obviously take that under advisement and see how much more clarity and transparency and information we can provide. Phil Nadeau -- Cowen and Company -- Analyst. And where will ULTOMIRIS fit in to the treatment paradigm in light of FcRns coming? But can you just clarify is, are you seeing in the field that NMO is indeed more resilient to COVID-19 disruptions than MG? Earnings announcement* for ALXN: May 05, 2021. gMG is just a function of our continued focus more on the depth side of prescribing and less so on breadth, for example, generating prescriptions with new first-time clinicians. And the other thing that is unique about SOLIRIS and then bridging to ULTOMIRIS is, we do firmly believe, given that this is a chronic disease in continuous noncyclical therapy. So we're quite emphatic about the continuous aspect of therapy. As we move forward, we will continue to invest in our existing pipeline to drive long-term value for patients and shareholders alike. Investors may trade in the Pre-Market (4:00-9:30 a.m. Thank you. ANDEXXA provides a solution for these patients through targeted and rapid reversal of factor Xa activity with a growing body of both clinical and real-world evidence that advances its value proposition. You are cautioned not to rely on Alexion’s and AstraZeneca’s forward-looking statements. While the final list of indications in the study is still under evaluation, we have identified lupus nephritis, IgA nephropathy, primary membranous nephropathy and C3G as a sampling of indications of interest. Building on this foundation, we see opportunity to diversify our business beyond C5 with four additional late-stage novel assets currently in scope. I'm very proud of our strong execution thus far in 2020, especially in the face of this challenging environment. OK. Your line is open. We have the flexibility now because of the strong execution but also because the situation that we are in with our R&D pipeline, which is much stronger than before. So taking all those factors into account is what our guidance is based on. The strength of our underlying business performance allows us to absorb the short-term dilution from the Portola transaction. Alexion Pharmaceuticals' (NASDAQ:ALXN) stock is up by a considerable 32% over the past three months. And so NMOSD continues to progress very nicely. It reported earnings per share of … We know the rare disease community has been greatly impacted, and we remain committed to supporting them. Chris Raymond -- Piper Sandler -- Analyst. And if you remember some of the commentary from the last quarter, we actually had talked about various controls and various things that changed in the opex, some of which were involuntary, for example, T&E expense and conference-related expenses and so forth and some of it were voluntary because of the uncertainty on the top line. Just sort of midpoint to midpoint, it's up $242 million, I think, if you back out the Portola component of that, of $125 million. So confident based on the Phase II data. Or do you expect initially at least this year to just offset employee stock option dilution? The study is planned in Japan, where we have been granted the SAKIGAKE designation by MHLW, one of the few foreign medicines to have received this distinction. While we did have to pause our subcutaneous single and multiple ascending dose program, early data showed single doses were well tolerated and had a meaningful IgG lowering potential. On the right, we lay out our proof-of-concept strategy in renal indications. Yes. As a reminder, we lowered our guidance in the first quarter with the assumption that we would start to see gradual reopening to healthcare systems around the globe in July. If you're committing to return of capital to investors in the midterm, why not issue a dividend? Cresud Shs Sponsored American Deposit Receipts Repr 10 Shs Q4 2020 Earnings Conference. Brian, I don't know if you want to add to the third question. Phil, I'll just jump in on the second question about neurology and potential new competitive entrants. It seems like you've highlighted a couple of headwinds in 2020 and specifically the second half, such as COVID and the conversion of patients from SOLIRIS on to ULTOMIRIS. Coupled with a convenient on-body device, we believe 1830 has potential to be a differentiated FcRn. Chris, yes, just on your second question. Thank you, Ludwig. Our next question comes from Geoffrey Porges from SVB Leerink. Longer term, we still expect ANDEXXA to achieve peak sales of at least $600 million and profitability aligned with historical Alexion margins. To this end, in addition to the $1 billion share repurchase authorization approved in October of 2019, the board has approved a further $1.5 billion authorization in support of this effort to maximize shareholder value. 1840 has the potential to be a transformative new standard of care in Wilson disease with its rapid onset of action, profound copper clearance and convenient once-daily oral dosing. But Aradhana, do you want to talk on this? The acquisition has the potential to advance the shared science-led mission of both companies to leverage complementary approaches to developing life-changing medicines. Here Are 3 Game-Changing Stocks to Buy, Got $1,000? With that, I'll turn the call over to Brian to provide commercial highlights from the quarter. And then have you contemplated providing long-term guidance? Your line is open. Ludwig Hantson -- Chief Executive Officer. And I expect that atypical HUS with ULTOMIRIS will really deliver for patients just as it has with PNH. The non-GAAP effective tax rate in the quarter was approximately 15%. As a result, GAAP earnings per share was a loss of $4.84. The fourth is the payer mix, which, again, takes a little bit time with the unemployment rates and so forth. As I'd mentioned, it could be up to 20,000 patients. This is one of the key drivers of success to our ambition of quadrupling the number of both gMG and NMOSD patients we treat in the U.S. by 2025. No offering of securities shall be made, except by means of a prospectus meeting the requirements of Section 10 of the U.S. Securities Act of 1933, as amended. And there continues to be uncertainty in the market moving forward. We have made substantial progress thus far and have created a strong foundation upon which we can continue to deliver. Aradhana Sarin — Executive Vice President, Chief Financial Officer. And I look forward to carrying this momentum into the rest of the year. You can access the webcast slides that will be presented on this call and other earnings materials by going to the events section of our investor relations page on our website. The payer mix takes time to go through, and we're watching that for the second half of the year as well. For the fourth quarter, Alexion earnings of $2.14 per share, on an adjusted basis, handily beat the estimate of analysts polled by Zacks Investment Research for $1.83. As a reminder, we made the strategic decision to lower the annual cost per patient on ULTOMIRIS compared to SOLIRIS. There's uncertainty around COVID and second wave and access and so forth. But we're looking at continuous therapy as opposed to cyclical therapy to avoid a loss of a treatment effect and carrying that response out throughout the full duration of the dosing interval. I know you've talked about a lot of puts and takes, but maybe just kind of walk through what sort of, I guess, sort of driving that? And with FcRn, where we're certainly with our own pipeline interested as well, that's more toward first-line displacement, IVIg, immunosuppressive therapies, high dose steroids and the like. Non-GAAP second quarter EPS was $3.11, growing 18% year over year. We will opportunistically consider additional repurchases above this amount as the market and business development landscape evolves. It has the opportunity to be the first subcutaneous treatment option for both PNH and atypical HUS and provides an additional treatment choice for patients who prefer to self-administer their medicine. It's event oriented. While it will take some time to execute fully, our teams have hit the ground running to lay the foundation, and I look forward to sharing additional updates on future calls. First of all, we're already under way now in Germany and thrilled about that with ULTOMIRIS for atypical HUS. As previously announced, we will be initiating basket trials with both ULTOMIRIS and 2050. The other part of the opex is, we had also anticipated perhaps delays in studies and, therefore, given the opex guidance appropriately. And with that in a subset of patients over half in the study 205 had meaningful reductions in proteinuria, which both our internal experts as well as external advisors believe is a meaningful impact on proteinuria that would not have been realized spontaneously. This resulted in reduced long-term cash flow projections and an impairment of our KANUMA intangible assets of approximately $2 billion. ET) and the After Hours Market (4:00-8:00 p.m. By using our website, you agree to our use of cookies in accordance with our, Alexion to Report Fourth Quarter and Full Year 2020 Results on Thursday, February 4, 2021. Moving to Slide 10. And as Brian mentioned, we have essentially pivoted a lot of our calling efforts and a lot of our strategies to more digital means, which obviously is not the same. We also hear the feedback and share the perspective that we are undervalued. This quarterly report represents an earnings surprise of 3.44%. We will be reinitiating the program in the first half of 2021. Head of Investor Relations I think from your answer to the last question, you guys mentioned that -- and you were talking about the differences in indications. Alexion Pharmaceuticals (ALXN) came out with quarterly earnings of $3.11 per share, beating the Zacks Consensus Estimate of $2.55 per share. And then the fourth factor that I mentioned was the payer mix, which also may take some time to play out and may have impact in 2021 as well. As we had previously shared, enrollment is complete in our Phase III Superiority Trial for ALXN1840 in Wilson disease, and we continue to plan for Phase III data in the first half of next year. Sep 30, 2020 • 01:00 pm ET. So, it's imperative that these patients get help quickly when they first present in the critical care setting. We will increase this to a minimum of 1/3 of our free cash flows on an average annually from 2021 to 2023. As Brian mentioned, our field force is not back yet.

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